The serum Glu, UA, TC and TG levels of middle-aged and elderly people directly reflect the status of glucose metabolism, purine metabolism and lipid metabolism of middle-aged and elderly people. As the physiological function of the body decreases with age, the glucose metabolism, renal function and lipid metabolism must be affected. In this study, we found that there was a significant increase in Glu with age. There is a certain relationship between blood lipid level and gender, and the TC level in men tends to reach a relative peak at the age of 50-60; with the increase of age, there is a tendency to decrease year by year. This may be related to the decrease in social activities (e.g., socializing) and lack of exercise in men as they age . TC levels in women over 50 years of age increased year by year and were significantly higher than those in men, which may be related to lower estrogen levels and less physical activity in women at higher ages, which is basically consistent with the literature . Lipid levels increased with age, with a peak at the age of 50-60 years. TC is an important causative factor for atherosclerosis and coronary artery disease, and recent studies have shown that hyper-TGemia is also an independent risk factor for the development of coronary artery disease. UA is the end product of purine metabolism and is the best biochemical indicator for the diagnosis of gout due to purine metabolism disorders. High serum UA levels are also closely related to diabetes mellitus, coronary heart disease and peripheral vascular disease . The incidence of high UA in the elderly is high and increases with age . Therefore, it is especially important to check blood UA regularly. In this study, UA levels differed significantly between age groups and were significantly higher in men than in women (P<0.05), and the rate of abnormal UA was also significantly higher in men than in women, so it should be taken seriously. Cardiovascular and cerebrovascular diseases are recognized by the World Health Organization as the "number one killer" of human health and have become the most common disease and cause of death, which is a common concern worldwide. Hyperlipidemia is the pathological basis of cardiovascular diseases . The results of this study showed that men had the highest rate of abnormal TC and women had the highest rate of abnormal TG; the levels of Glu, UA, TC and TG were different among different ages and genders. Therefore, the respective reference intervals should be established according to different ages and genders to effectively avoid underdiagnosis and misdiagnosis. At the same time, in view of the increase in the number of subhealthy people, we should vigorously promote health care knowledge, strengthen the awareness of self-care of middle-aged and elderly people, and increase the strength and breadth of health checkups. This is of great significance to prevent and control the occurrence and development of various diseases.
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